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Section Navigation

  • How to use a custom force field with amber.build
  • How to mix AMBER protein with OpenFF small-molecule parameters
  • How to add a covalent crosslink by hand
  • How to set up an asymmetric bilayer
  • How to embed a protein in a pre-equilibrated membrane
  • How to configure adaptive sampling parameters
  • How to write a custom goal function for AdaptiveGoal
  • How to inspect a finished adaptive run
  • How to build a simlist from a non-standard directory layout
  • How to filter trajectories with simfilter
  • How to drop bad trajectories from an MSM dataset
  • How to bootstrap an MSM for error bars on timescales
  • How to read off and interpret an implied-timescales plot
  • How to plot a free-energy surface from an MSM
  • How to extract a representative structure per macrostate
  • How to evaluate force-field energies on a frame
  • How to generate docking poses for downstream MD
  • How-to guides

How-to guides#

Task-oriented recipes. Each page solves one concrete problem; pick the one matching your situation. Molecule-level recipes (reading, selection, wrapping, projections, …) live in moleculekit’s how-to guides - the pages here cover the HTMD layer above that (system building, simulation orchestration, MSM analysis).

System building#

  • How to use a custom force field with amber.build
  • How to mix AMBER protein with OpenFF small-molecule parameters
  • How to add a covalent crosslink by hand

Membranes#

  • How to set up an asymmetric bilayer
  • How to embed a protein in a pre-equilibrated membrane

Adaptive sampling#

  • How to configure adaptive sampling parameters
  • How to write a custom goal function for AdaptiveGoal
  • How to inspect a finished adaptive run

MSM analysis#

  • How to build a simlist from a non-standard directory layout
  • How to filter trajectories with simfilter
  • How to drop bad trajectories from an MSM dataset
  • How to bootstrap an MSM for error bars on timescales
  • How to read off and interpret an implied-timescales plot
  • How to plot a free-energy surface from an MSM
  • How to extract a representative structure per macrostate

Force-field and docking tools#

  • How to evaluate force-field energies on a frame
  • How to generate docking poses for downstream MD

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Adaptive Bandit

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How to use a custom force field with amber.build

On this page
  • System building
  • Membranes
  • Adaptive sampling
  • MSM analysis
  • Force-field and docking tools
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